GLUCOVANCE 500MG/2.5MG 30'S

Glucovance 500/2.5 mg is a combination oral medication prescribed for the treatment of type 2 diabetes mellitus when monotherapy with either metformin or sulfonylurea alone is inadequate for blood glucose control. The tablet contains two active ingredients: Metformin Hydrochloride (500 mg): A biguanide that lowers blood glucose levels primarily by decreasing hepatic glucose production, improving insulin sensitivity, and reducing glucose absorption from the gut. Glibenclamide (2.5 mg): A sulfonylurea that stimulates pancreatic beta cells to release insulin, increasing insulin availability to lower blood sugar. This combination offers a complementary mechanism of action, helping patients achieve better glycemic control. The lower dose of glibenclamide is often preferred for patients who are more sensitive to sulfonylureas or are at increased risk of hypoglycemia. Glucovance tablets should be taken orally, typically once or twice daily with meals to reduce gastrointestinal side effects and minimize the risk of low blood sugar. Patients must follow their healthcare provider’s directions carefully and undergo regular monitoring of blood glucose and kidney function. The medication is contraindicated in patients with severe renal or hepatic impairment and those with a history of lactic acidosis. Caution is advised when treating elderly patients or those with comorbid conditions. Common side effects include mild gastrointestinal discomfort and risk of hypoglycemia due to glibenclamide. Patients should seek medical attention if they experience severe adverse effects or symptoms of lactic acidosis.